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ONCOSTATIN M (OSM) IS INCREASED IN ASTHMA WITH INCOMPLETELY REVERSIBLE AIRFLOW OBSTRUCTION.
- Source :
-
Experimental Lung Research . Nov2009, Vol. 35 Issue 9, p781-794. 14p. 1 Color Photograph, 2 Charts, 4 Graphs. - Publication Year :
- 2009
-
Abstract
- Oncostatin M, a unique member of the interleukin (IL)-6 cytokine family, is thought to be involved in airway remodeling. The expression of oncostatin M in the lower airways is unknown. The aim of this study was to measure the sputum expression of oncostatin M in patients with asthma with and without irreversible airflow obstruction. Induced sputum was collected from nonsmoking adults with stable asthma (n = 53), 31 with incomplete reversibility of airflow obstruction. Peripheral blood cells were isolated and stimulated with lipopolysaccharide in 10 participants with asthma and irreversible airflow obstruction. Oncostatin M protein levels were determined in supernatant, whereas RNA was extracted to determine Oncostatin M mRNA expression using real-time polymerase chain reaction (PCR). Oncostatin M mRNA expression and protein levels were significantly higher in the sputum of asthmatics with irreversible airflow obstruction. Sputum oncostatin M levels were highest in people with severe airflow obstruction and were localized to airway neutrophils and macrophages. Peripheral blood neutrophils released more oncostatin M when stimulated with lipopolysaccharide compared with unstimulated neutrophils. Sputum oncostatin M is increased in asthma with irreversible airflow obstruction and is present in airway neutrophils and macrophages. Oncostatin M may link airway inflammation to remodeling in asthma. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01902148
- Volume :
- 35
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Experimental Lung Research
- Publication Type :
- Academic Journal
- Accession number :
- 45197303
- Full Text :
- https://doi.org/10.3109/01902140902906412