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25-Hydroxyvitamin D in cerebrospinal fluid during relapse and remission of multiple sclerosis.
- Source :
-
Multiple Sclerosis (13524585) . Nov2009, Vol. 15 Issue 11, p1280-1285. 6p. 1 Chart, 4 Graphs. - Publication Year :
- 2009
-
Abstract
- Hypovitaminosis D may play a role in multiple sclerosis (MS), but little is known about intrathecal vitamin D. 25-Hydroxyvitamin D was measured in cerebrospinal fluid and sera from 36 patients with relapsing-remitting MS, 20 patients with other inflammatory neurological diseases and 18 patients with non-inflammatory neurological diseases with liquid chromatography-mass spectrometry. There were no significant differences in cerebrospinal fluid concentrations of 25-hydroxyvitamin D, but the cerebrospinal fluid : serum ratio was significantly lower in MS compared with other inflammatory neurological diseases (p = 0.0012) and non-inflammatory neurological diseases (p = 0.041) patients. The concentrations of 25-hydroxyvitamin D in cerebrospinal fluid and serum were positively correlated and their ratio was similar to that of albumin. Neither the concentrations of 25-hydroxyvitamin D in cerebrospinal fluid or serum nor their ratio were associated with the presence of relapses or gadolinium-enhanced lesions. These results do not support that 25-hydroxyvitamin D is actively transported to the cerebrospinal fluid, or that the cerebrospinal fluid or serum levels or their ratio exert a major impact on MS activity. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 13524585
- Volume :
- 15
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Multiple Sclerosis (13524585)
- Publication Type :
- Academic Journal
- Accession number :
- 45122264
- Full Text :
- https://doi.org/10.1177/1352458509107008