Back to Search Start Over

A new bifunctional GdIIIcomplex of enhanced efficacy for MR-molecular imaging applicationsElectronic supplementary information (ESI) available: Synthesis and characterization of ligands L1, L2, L3and L4; 1H relaxation rates as a function of temperature for the corresponding Gd complexes at 30 MHz. See DOI: 10.1039/b917566k

A new bifunctional GdIIIcomplex of enhanced efficacy for MR-molecular imaging applicationsElectronic supplementary information (ESI) available: Synthesis and characterization of ligands L1, L2, L3and L4; 1H relaxation rates as a function of temperature for the corresponding Gd complexes at 30 MHz. See DOI: 10.1039/b917566k

Authors :
Tei, Lorenzo
Gugliotta, Giuseppe
Baranyai, Zsolt
Botta, Mauro
Source :
Dalton Transactions: An International Journal of Inorganic Chemistry. Nov2009, Vol. 2009 Issue 44, p9712-9714. 3p.
Publication Year :
2009

Abstract

Increasing the length of the carboxyamide arm of a GdDOTA monoamide (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) complex from acetic to propionic accelerates the water exchange rate (kex) by nearly two orders of magnitude; the 1H relaxivity of the corresponding macromolecular derivatives may then be remarkably enhanced in MRI-based molecular imaging applications, as exemplified in the case of micellar systems. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14779226
Volume :
2009
Issue :
44
Database :
Academic Search Index
Journal :
Dalton Transactions: An International Journal of Inorganic Chemistry
Publication Type :
Academic Journal
Accession number :
44975397
Full Text :
https://doi.org/10.1039/b917566k