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A new bifunctional GdIIIcomplex of enhanced efficacy for MR-molecular imaging applicationsElectronic supplementary information (ESI) available: Synthesis and characterization of ligands L1, L2, L3and L4; 1H relaxation rates as a function of temperature for the corresponding Gd complexes at 30 MHz. See DOI: 10.1039/b917566k
A new bifunctional GdIIIcomplex of enhanced efficacy for MR-molecular imaging applicationsElectronic supplementary information (ESI) available: Synthesis and characterization of ligands L1, L2, L3and L4; 1H relaxation rates as a function of temperature for the corresponding Gd complexes at 30 MHz. See DOI: 10.1039/b917566k
- Source :
-
Dalton Transactions: An International Journal of Inorganic Chemistry . Nov2009, Vol. 2009 Issue 44, p9712-9714. 3p. - Publication Year :
- 2009
-
Abstract
- Increasing the length of the carboxyamide arm of a GdDOTA monoamide (DOTA = 1,4,7,10-tetraaza-1,4,7,10-tetrakis(carboxymethyl)cyclododecane) complex from acetic to propionic accelerates the water exchange rate (kex) by nearly two orders of magnitude; the 1H relaxivity of the corresponding macromolecular derivatives may then be remarkably enhanced in MRI-based molecular imaging applications, as exemplified in the case of micellar systems. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14779226
- Volume :
- 2009
- Issue :
- 44
- Database :
- Academic Search Index
- Journal :
- Dalton Transactions: An International Journal of Inorganic Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 44975397
- Full Text :
- https://doi.org/10.1039/b917566k