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Approach to Tetrodotoxin via the Oxidative Amidation of a Phenol.
- Source :
-
Organic Letters . Oct2009, Vol. 11 Issue 20, p4736-4739. 4p. - Publication Year :
- 2009
-
Abstract
- An approach to tetrodotoxin that relies on the oxidative amidation of methyl 4-hydroxyphenylacetate as a key step is described. The stereoselective introduction of a β-hydroxynitrile functionality on one of the double bonds of the emerging dienone is achieved through an intramolecular nitrile oxide cycloaddition−fragmentation sequence. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 15237060
- Volume :
- 11
- Issue :
- 20
- Database :
- Academic Search Index
- Journal :
- Organic Letters
- Publication Type :
- Academic Journal
- Accession number :
- 44777222
- Full Text :
- https://doi.org/10.1021/ol901914u