Back to Search Start Over

Enantioselective synthesis of quaternary stereogenic centers through catalytic asymmetric addition of dimethylzinc to α-ketoesters with chiral cis-cyclopropane-based amide alcohol as ligand

Authors :
Zheng, Bing
Hou, Shicong
Li, Zhiyuan
Guo, Hongchao
Zhong, Jiangchun
Wang, Min
Source :
Tetrahedron: Asymmetry. Sep2009, Vol. 20 Issue 18, p2125-2129. 5p.
Publication Year :
2009

Abstract

Abstract: A new amino alcohol with a chiral cyclopropane backbone has been developed and used in the catalytic asymmetric diethylzinc addition to various types of α-ketoesters. This cyclopropane-based chiral amino alcohol shows moderate enantioselectivity in the addition of organozinc to α-ketoesters. For dimethylzinc addition to α-ketoesters, up to 81% ee are obtained, respectively. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
09574166
Volume :
20
Issue :
18
Database :
Academic Search Index
Journal :
Tetrahedron: Asymmetry
Publication Type :
Academic Journal
Accession number :
44697279
Full Text :
https://doi.org/10.1016/j.tetasy.2009.07.050