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Evaluation of the 24-Hour Profiles of Physiological Insulin, Glucose, and C-Peptide in Healthy Japanese Volunteers.
- Source :
-
Diabetes Technology & Therapeutics . Aug2009, Vol. 11 Issue 8, p499-508. 10p. - Publication Year :
- 2009
-
Abstract
- AbstractBackground:Some studies have demonstrated the benefit of blood glucose control as close as possible to physiological conditions. Not enough reports have investigated in detail the 24-h plasma profiles of insulin/glucose/C-peptide. Here we investigated the 24-h plasma profiles of physiological insulin/glucose/C-peptide in healthy Japanese adults.Methods:In order to evaluate the 24-h profiles of physiological insulin/glucose/C-peptide profiles, 42 blood samples were taken from each subject in our group of healthy Japanese volunteers to measure the 24-h profile with three standardized meals.Results:Plasma glucose and insulin increased rapidly followed by a rapid decrease after each meal with little variation at night. The average peak values of insulin after each meal were as follows: 426.20 pmol/L (breakfast), 373.75 pmol/L (lunch), and 410.28 pmol/L (dinner). The average times to peak insulin were 0.651 h (breakfast), 0.677 h (lunch), and 0.689 h (dinner). The corresponding average maximum postprandial plasma glucose levels were 8.39 mmol/L (breakfast), 8.77 mmol/L (lunch), and 8.74 mmol/L (dinner). The average times to peak glucose were 0.738 h (breakfast), 0.650 h (lunch), and 0.625 h (dinner). The average maximum postprandial C-peptide levels were 2.64 nmol/L (breakfast), 2.55 nmol/L (lunch), and 2.67 nmol/L (dinner). No major differences were found in these parameters between the Caucasian and Japanese populations.Conclusions:This is the first investigation to measure the 24-h profiles of insulin/glucose/C-peptide in healthy Japanese volunteers with standardized meals. It is hoped this information will provide useful reference for future research and clinical management. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BLOOD testing
*INSULIN
*C-peptide
*BLOOD sugar
*JAPANESE people
*BLOOD plasma
*HEALTH
Subjects
Details
- Language :
- English
- ISSN :
- 15209156
- Volume :
- 11
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Diabetes Technology & Therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 44510250
- Full Text :
- https://doi.org/10.1089/dia.2009.0029