A four-component, one-pot synthesis of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamides

Authors :: Shaabani, Ahmad
Seyyedhamzeh, Mozhdeh
Maleki, Ali
Behnam, Maryam
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Nov2009, Vol. 50 Issue 46, p6355-6357. 3p.
Publication Year :: 2009
Abstract: Abstract: A new, one-pot, four-component reaction for the synthesis of a novel class of highly substituted 1,4-dihydro-1,8-naphthyridine-3-carboxamide derivatives starting from readily available inputs including aliphatic or aromatic amines, diketene, aromatic aldehydes, and 2-aminopyridines in the presence of a catalytic amount of p-toluenesulfonic acid under mild reaction conditions and in good yields at ambient temperature is described. [Copyright &y& Elsevier]

Subjects :: *AMIDES
*NAPHTHYRIDINES
*ORGANIC synthesis
*AROMATIC amines
*ALDEHYDES
*SULFONIC acids
*CATALYSTS
*TEMPERATURE effect

Language :: English
ISSN :: 00404039
Volume :: 50
Issue :: 46
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 44470041
Full Text :: https://doi.org/10.1016/j.tetlet.2009.08.104

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