BORUN SIÇAN TESTİS DOKUSUNA ETKİLERİ.

Borax (B); is an important trace element playing a role in cell membrane functions, mineral and hormonal metabolisms and enzyme reactions. Consequently B; is at the same time related to osteoporosis, heart trouble, paralysis, diabetes, senility and particularly some changes on reproductive system. It is known testis is one of the organs that has been maximum affected from B, however there are not enough number of studies relevant with this subject at microscobic level. Therefore in our study, chronic borax application effects on rat testis are analysed at microscobic level. In this study 250-300 gr weight of 14 male albino Spraque-Dawley type of rat are used. 7 rat as cotrol group, 7 rat as experimental group are separated from these subjects. 300 mg/L borax is given in their drinking water for 70 days duration to experimental group of rat. By the end of 70th day, rat are sacrificed by giving pentobarbital (65 mg/kg) anaesthesia with intraperitoneal via and right and left testis tissues of rat are taken. Taken tissues are analysed by doing routine light and electron microscobic follows. In microscobic analyses within control group basal lamina, seminiferous tubule structures, interstisial area and Leydig cells found in this area are observed in normal structure. As in borax applied experimental group; numeric increase is observed as vacuolisation and residual structures in spermatogoniums. Any damage in Leydig cells hasn't been diagnosed also. In our study, it is observed that borax has not formed any serious damage dependent on applied dosage and duration. [ABSTRACT FROM AUTHOR]