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Sequential tests and estimators after overrunning based on maximum‐likelihood ordering.

Authors :
Hall, W. J.
Liu, Aiyi
Source :
Biometrika. Sep2002, Vol. 89 Issue 3, p699-708. 10p.
Publication Year :
2002

Abstract

Often in sequential trials some additional data become available after a stopping boundary has been reached. A method for incorporating such information from overrunning is developed, based on a maximum‐likelihood ordering of the sample space after overrunning. This yields a p‐value for the primary test and a median‐unbiased estimator and confidence intervals for the parameter under test. The context is that of observing a Brownian motion with drift, with either linear stopping boundaries in continuous time or discrete‐time group‐sequential boundaries. The methods apply to many clinical trials and are exemplified with data from a survival‐analysis‐based sequential clinical trial. [ABSTRACT FROM PUBLISHER]

Details

Language :
English
ISSN :
00063444
Volume :
89
Issue :
3
Database :
Academic Search Index
Journal :
Biometrika
Publication Type :
Academic Journal
Accession number :
44401201
Full Text :
https://doi.org/10.1093/biomet/89.3.699