Inflammation-induced up-regulation of ionotropic glutamate receptor expression in human skin.

Background: N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazolone-4-propionic acid (AMPA), and kainate (KA) receptors are members of the ionotropic glutamate receptor (iGluR) family and are increased in inflamed rat skin. These receptors contribute to inflammatory pain. In this study, we have examined whether there is a similar increase in iGluRs in inflamed human skin in the presence of inflammatory pain. [ABSTRACT FROM PUBLISHER]