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Body weight variation and control of cardiovascular risk factors in essential hypertension.

Authors :
Pascual, Jose Maria
Rodilla, Enrique
Costa, Jose Antonio
Perez-Lahiguera, Francisco
Gonzalez, Carmen
Lurbe, Empar
Redón, Josep
Source :
Blood Pressure. Oct2009, Vol. 18 Issue 5, p247-254. 8p. 5 Charts.
Publication Year :
2009

Abstract

Objective. The objective was to assess the impact of weight changes on blood pressure (BP), lipids and glucose goals in a cohort of hypertensive subjects. Design. Prospective follow-up. Setting. Hypertension clinic. Patients. 326 hypertensive non-diabetic subjects, 46% with metabolic syndrome (MS). Interventions. Usual care treatment, which included diet, physical exercise and drugs prescribed when indicated. All patients were observed for up to 1 year. Main outcome measures. BP and low-density lipoprotein-cholesterol (LDL-C) goal were those in ESH/ESC and ATP III recommendations, respectively. The glucose goal was to delay progression to type 2 diabetes mellitus, or to achieve blood glucose <100mg/dl for non-diabetics. According to body weight changes, patients were categorized using adjusted ROC curves models. Results. Overall, there was a significant weight increment of 0.5kg (95% CI 0.1-0.9kg); 28 patients (8.6%) lost more than 5kg, and only four (1.2%) lost more than 10kg. BP, LDL-C and glucose goals were achieved in 56%, 78% and 61% of patients, respectively. To lose or not gain weight was an independent prognostic factor to achieve the BP goal in all the patients and the LDL goal in the presence of MS. For glucose control, being treated with beta-blockers and/or diuretics was a negative factor. Conclusions. In hypertensive subjects, even small changes in weight may have an important impact on achieving cardiovascular goals, mainly in those with MS. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
08037051
Volume :
18
Issue :
5
Database :
Academic Search Index
Journal :
Blood Pressure
Publication Type :
Academic Journal
Accession number :
44375633
Full Text :
https://doi.org/10.1080/08037050903244791