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Neonatal Exposure to Fenoterol and Betamethasone: Effects on the Behavioral Development in the Rat.
- Source :
-
International Journal of Neuroscience . Oct2009, Vol. 119 Issue 10, p1548-1571. 24p. 5 Graphs. - Publication Year :
- 2009
-
Abstract
- We investigated longitudinally the behavioral development in the rat following exposure to β-agonists and glucocorticoids (GC). Neonatal rats received either 1 mg/kg fenoterol (FEN), 0.3 mg/kg betamethasone (BET), or saline (SAL). Weanling and young adult rats were tested in the open field, the elevated-plus maze, and the water maze. FEN-treated as well as BET-treated animals displayed increased anxiety-like behavior. Furthermore, BET-treated adult animals showed a reduced locomotor activity. An enhanced 24-h memory in the water maze in both treatment groups may be facilitated by emotional arousal due to the increased anxiety levels. The possible neurobiological underpinnings are discussed in detail. [ABSTRACT FROM AUTHOR]
- Subjects :
- *FENOTEROL
*BRONCHODILATOR agents
*GLUCOCORTICOIDS
*ANXIETY
*RATS
Subjects
Details
- Language :
- English
- ISSN :
- 00207454
- Volume :
- 119
- Issue :
- 10
- Database :
- Academic Search Index
- Journal :
- International Journal of Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 44192617
- Full Text :
- https://doi.org/10.1080/00207450802323947