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Intrahepatic PD-1/PD-L1 Up-regulation Closely Correlates with Inflammation and Virus Replication in Patients with Chronic HBV Infection.
- Source :
-
Immunological Investigations . Oct2009, Vol. 38 Issue 7, p624-638. 15p. 2 Black and White Photographs, 1 Chart, 1 Graph. - Publication Year :
- 2009
-
Abstract
- Chronic hepatitis B was characterized by fluctuant immune response to infected hepatocytes resulting in hepatic inflammation and virus persistence. Recently, Programmed Death-1 (PD-1) and its ligand PD-L1 have been demonstrated to play an essential role in balancing antiviral immunity and inflammation in the livers of acute hepatitis B patients, significantly influencing disease outcome. PD-1 up-regulation in peripheral T cells is associated with immune dysfunction in chronic hepatitis B patients. However, the effect of PD-1/PD-L1 on hepatic damage and chronic infective status is still unknown in patients with chronic HBV infection. Here, we report up-regulation of PD-1 and PD-L1 in liver biopsies from 32 chronic HBV patients compared to 4 healthy donors. PD-1/PD-L1 up-regulation was significantly associated with hepatic inflammation and ALT elevation. Moreover, appropriate up-regulation but not overexpression of PD-L1 in the active phase of chronic hepatitis B as well as lower expression of PD-L1 in the inactive phase in liver residential antigen presenting cells (including Kupffer cells and sinusoidal endothelial cells) may contribute to viral inhibition. Our data suggest that the intrahepatic interaction of PD-1 and PD-L1 might play an important role in balancing the immune response to HBV and immune-mediated liver damage in chronic HBV infection. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATITIS B
*CHRONIC diseases
*IMMUNE response
*LIVER cells
*LIVER diseases
Subjects
Details
- Language :
- English
- ISSN :
- 08820139
- Volume :
- 38
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Immunological Investigations
- Publication Type :
- Academic Journal
- Accession number :
- 44192542
- Full Text :
- https://doi.org/10.1080/08820130903062210