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Lithium Chloride-Assisted Selective Hydrolysis of Methyl Esters Under Microwave Irradiation.
- Source :
-
Synthetic Communications . 2009, Vol. 39 Issue 19, p3459-3470. 12p. 1 Diagram, 4 Charts. - Publication Year :
- 2009
-
Abstract
- A rapid and mild method for the selective hydrolysis of methyl ester in lithium chloride-N,N-dimethylformamide (LiCl-DMF) system under microwave irradiation has been developed. The effects of substituent, metal salt, and solvent on the reactivity and selectivity of the hydrolysis reaction have been investigated. Microwave irradiation significantly improves the reaction yield within a short time in an LiCl-DMF system. Moreover, the chiral α-carbon of methyl esters retained its configuration during the reaction. Finally, the catalytic mechanism of hydrolysis by LiCl salt has also been proposed. [ABSTRACT FROM AUTHOR]
- Subjects :
- *LITHIUM chloride
*HYDROLYSIS
*ESTERS
*ORGANIC compounds
*IRRADIATION
Subjects
Details
- Language :
- English
- ISSN :
- 00397911
- Volume :
- 39
- Issue :
- 19
- Database :
- Academic Search Index
- Journal :
- Synthetic Communications
- Publication Type :
- Academic Journal
- Accession number :
- 44081343
- Full Text :
- https://doi.org/10.1080/00397910902778001