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Association Between MGMT Promoter Hypermethylation and p53 Mutation in Glioblastoma.
- Source :
-
Cancer Investigation . Oct2009, Vol. 27 Issue 8, p825-829. 5p. 3 Color Photographs, 1 Diagram, 1 Chart. - Publication Year :
- 2009
-
Abstract
- O6-methylguanine-DNA methyltransferase (MGMT) is a DNA repair enzyme that removes alkyl groups from the O6 position of guanine. MGMT is transcriptionally silenced by promoter hypermethylation in several human neoplasia. We used methylation-specific PCR (MSP) to analyze the MGMT promoter methylation status of 50 glioblastoma tumors. Hypermethylation was detected in 24 of 50 (48%) samples. We also analyzed mutant p53 expression by immunohistochemical analysis of glaioblastoma tissue samples. A significant association was found between MGMT methylation and p53 mutation status (p< .05). These results suggested that epigenetic inactivation of MGMT plays an important role in the survival of glioblastoma patients and this inactivated gene involved in p53 mutation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *METHYLATION
*BIOCHEMICAL genetics
*DNA repair
*NUCLEIC acids
*ANTIMUTAGENS
Subjects
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 27
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 44032830
- Full Text :
- https://doi.org/10.1080/07357900902783211