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A Cascade Approach to Cyclic Aminonitrones: Reaction Discovery, Mechanism, and Scope.

Authors :
Rojita Sharma
Paul G. Bulger
Michael McNevin
Peter G. Dormer
Richard G. Ball
Eric Streckfuss
James F. Cuff
Jingjun Yin
Cheng-yi Chen
Source :
Organic Letters. Aug2009, Vol. 11 Issue 15, p3194-3197. 4p.
Publication Year :
2009

Abstract

Treatment of ω-epoxynitriles with hydroxylamine affords cyclic aminonitrones in a single step and with high stereoselectivity. The scope of this novel transformation was explored in a series of examples. The aminonitrone products were shown to be useful substrates for further selective elaboration. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
15237060
Volume :
11
Issue :
15
Database :
Academic Search Index
Journal :
Organic Letters
Publication Type :
Academic Journal
Accession number :
43986600
Full Text :
https://doi.org/10.1021/ol9010147