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Up-regulation of CD44 in rheumatoid chondrocytes.
- Source :
-
Scandinavian Journal of Rheumatology . Mar2001, Vol. 30 Issue 2, p110-113. 4p. 4 Diagrams, 2 Graphs. - Publication Year :
- 2001
-
Abstract
- The adhesion molecule CD44 is thought to play an important role in the inflammatory process. To identify the expression of CD44 in articular chondrocytes in rheumatoid arthritis (RA), monoclonal anti-CD44 antibodies were immunohistochemically used to react with articular cartilage specimens of 15 patients with RA, 9 with osteoarthritis (OA), and 6 with femoral neck fracture (FF). The proportion of CD44-positive chondrocytes in RA was 93 +/- 2% (N=16), which was significantly higher than that in OA (59 +/- 7%, N=9, p<0.001) and FF (46 +/- 5%, N=6, p<0.001). Among CD44 isoforms examined, the hemopoietic form was dominant in chondrocytes in RA. Therefore, up-regulation of CD44 on chondrocytes may play a significant role in cartilage degeneration in RA. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CELL adhesion molecules
*RHEUMATOID arthritis
*CARTILAGE cells
Subjects
Details
- Language :
- English
- ISSN :
- 03009742
- Volume :
- 30
- Issue :
- 2
- Database :
- Academic Search Index
- Journal :
- Scandinavian Journal of Rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 4394547
- Full Text :
- https://doi.org/10.1080/03009740151095420