Back to Search
Start Over
NAD(P)H: Quinone oxidoreductase 1, glutathione S-transferase M1, environmental tobacco smoke exposure, and childhood asthma
- Source :
-
Mutation Research - Genetic Toxicology & Environmental Mutagenesis . Aug2009, Vol. 678 Issue 1, p53-58. 6p. - Publication Year :
- 2009
-
Abstract
- Abstract: Environmental tobacco smoke (ETS) exposure might increase the risk for childhood asthma, and we hypothesized the effect may be modified by the phase II genes NAD(P)H: quinone oxidoreductase 1 (NQO1) and glutathione S-transferase (GST) M1. To investigate the genetic and environmental associations with asthma, GSTM1 and NQO1 functional polymorphisms and ETS were analyzed in a two-staged cross-sectional study among elementary schoolchildren in Taiwan. Multiple logistic regression analysis revealed a significant association between the Ser allele of the NQO1 Pro187Ser polymorphism and asthma (OR=1.6, 95% CI 1.3–1.8). Although GSTM1 genotype itself was not significantly associated with asthma (OR=1.0, 95% CI 0.8–1.1), the GSTM1 genotype modified the association between the NQO1 polymorphism and asthma in children exposed to ETS (p =0.0002). The NQO1 gene might be involved in the development of asthma, especially in children carrying the GSTM1 null genotype who are exposed to ETS. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 13835718
- Volume :
- 678
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Mutation Research - Genetic Toxicology & Environmental Mutagenesis
- Publication Type :
- Academic Journal
- Accession number :
- 43770311
- Full Text :
- https://doi.org/10.1016/j.mrgentox.2009.06.008