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Magnetic resonance imaging tracking of alginate beads used for drug delivery of growth factors at sites of cardiac damage

Magnetic resonance imaging tracking of alginate beads used for drug delivery of growth factors at sites of cardiac damage

Authors :
Gruwel, Marco L.H.
Yang, Yanmin
de Gervai, Patricia
Sun, Jiankang
Kupriyanov, Valery V.
Source :
Magnetic Resonance Imaging (0730725X). Sep2009, Vol. 27 Issue 7, p970-975. 6p.
Publication Year :
2009

Abstract

Abstract: Alginate-based beads labeled with contrast agent and loaded with vascular growth hormones were used for site-specific chronic delivery of hormones at the site of myocardial damage in a porcine model. Position of the beads within the pericardium could be monitored by MRI for optimal hormone delivery due to the presence of contrast agent. The beads facilitate the slow release of cytochrome c, myoglobin and methemoglobin used as protein models of growth factors. This application allows for site-specific delivery of hormones while the incorporated contrast agent in the beads provides a tool for MRI tracking in chronic studies. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
0730725X
Volume :
27
Issue :
7
Database :
Academic Search Index
Journal :
Magnetic Resonance Imaging (0730725X)
Publication Type :
Academic Journal
Accession number :
43768155
Full Text :
https://doi.org/10.1016/j.mri.2009.01.023