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Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells.
- Source :
-
Nature Medicine . Aug2009, Vol. 15 Issue 8, p876-878. 3p. 2 Graphs. - Publication Year :
- 2009
-
Abstract
- The mechanisms underlying possible increased HIV-1 acquisition in adenovirus 5 (Ad5)-seropositive subjects vaccinated with Ad5–HIV-1 vectors in the Merck STEP trial remain unclear. We find that Ad5 serostatus does not predict Ad5-specific CD4+ T cell frequency, and we did not observe durable significant differences in Ad5-specific CD4+ T cells between Ad5-seropositive and Ad5-seronegative subjects after vaccination. These findings indicate no causative role for Ad5-specific CD4+ T cells in increasing HIV-1 susceptibility in the STEP trial. [ABSTRACT FROM AUTHOR]
- Subjects :
- *AIDS vaccines
*T cells
*ADENOVIRUS diseases
*VACCINATION
Subjects
Details
- Language :
- English
- ISSN :
- 10788956
- Volume :
- 15
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Nature Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 43579433
- Full Text :
- https://doi.org/10.1038/nm.1989