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Molecular imaging in neuroendocrine tumors: Molecular uptake mechanisms and clinical results
- Source :
-
Critical Reviews in Oncology/Hematology . Sep2009, Vol. 71 Issue 3, p199-213. 15p. - Publication Year :
- 2009
-
Abstract
- Abstract: Neuroendocrine tumors can originate almost everywhere in the body and consist of a great variety of subtypes. This paper focuses on molecular imaging methods using nuclear medicine techniques in neuroendocrine tumors, coupling molecular uptake mechanisms of radiotracers with clinical results. A non-systematic review is presented on receptor based and metabolic imaging methods. Receptor-based imaging covers the molecular backgrounds of somatostatin, vaso-intestinal peptide (VIP), bombesin and cholecystokinin (CCK) receptors and their link with nuclear imaging. Imaging methods based on specific metabolic properties include meta-iodo-benzylguanide (MIBG) and dimercapto-sulphuric acid (DMSA-V) scintigraphy as well as more modern positron emission tomography (PET)-based methods using radio-labeled analogues of amino acids, glucose, dihydroxyphenylalanine (DOPA), dopamine and tryptophan. Diagnostic sensitivities are presented for each imaging method and for each neuroendocrine tumor subtype. Finally, a Forest plot analysis of diagnostic performance is presented for each tumor type in order to provide a comprehensive overview for clinical use. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 10408428
- Volume :
- 71
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Critical Reviews in Oncology/Hematology
- Publication Type :
- Academic Journal
- Accession number :
- 43527290
- Full Text :
- https://doi.org/10.1016/j.critrevonc.2009.02.009