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Percutaneous Coronary Interventions Affect Concentrations of Interleukin 6 and Its Soluble Receptors in Coronary Sinus Blood in Patients With Stable Angina.
- Source :
-
Angiology . Jun/Jul2009, Vol. 60 Issue 3, p322-328. 7p. - Publication Year :
- 2009
-
Abstract
- Coronary stenting may create local inflammatory reaction. Interleukin 6 effects depend on the presence of soluble receptors (sIL-6R and sgp130) that facilitate or impede interleukin 6 signal transduction. Concentrations of interleukin 6 and its soluble receptors were assessed in aorta and coronary sinus after stenting in optimally treated stable angina patients scheduled for elective stenting. Baseline levels of interleukin 6 and its soluble receptors in patients did not differ from healthy controls. Initial levels of sIL-6R in aorta were significantly higher than in coronary sinus but this difference disappeared after intervention. Stenting caused interleukin 6 concentration increase to a similar extent both in coronary sinus and in aorta. Moreover, there was significantly higher sgp130 concentration in coronary sinus than in aorta. Coronary intervention increases concentration of interleukin 6 in patients with stable angina. It affects the cardiac level of interleukin 6 soluble receptors what may influence the local inflammatory reaction. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INTERLEUKIN-6
*ANGINA pectoris
*INFLAMMATION
*MICROBIAL genetics
*BACTERIOPHAGES
Subjects
Details
- Language :
- English
- ISSN :
- 00033197
- Volume :
- 60
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 43450616
- Full Text :
- https://doi.org/10.1177/0003319708330008