Back to Search
Start Over
Enhanced cellular uptake of chlorine e6 mediated by stearic acid–grafted chitosan oligosaccharide micelles.
- Source :
-
Journal of Drug Targeting . Jun2009, Vol. 17 Issue 5, p384-391. 8p. 2 Black and White Photographs, 1 Chart, 6 Graphs. - Publication Year :
- 2009
-
Abstract
- Chlorines are attractive compounds for photodynamic therapy because of their high absorption in the red wavelength region. The stearic acid–grafted chitosan oligosaccharide (CSO-SA) micelles have been presented as potential candidates for intracellular drug delivery carrier because of their special structure. In this study, CSO-SA micelles were prepared to encapsulate chlorine e6 (Ce6). The physicochemical properties of synthesized CSO-SA micelles were characterized. The critical micelle concentration (CMC) of CSO-SA with 4.96% amino substituted degree (SD %) was about 36.27 ± 1.51 μg/mL. The Ce6-loaded CSO-SA micelles were then prepared by a dialysis method, and the properties and drug release profiles of Ce6-loaded CSO-SA micelles (CSO-SA/Ce6) were investigated. The loading of Ce6 in the CSO-SA micelles could reach higher drug encapsulation efficiency (%), which was ~100%. The size of CSO-SA/Ce6 decreased after the loading of Ce6. The zeta potential of CSO-SA/Ce6 and the drug release rate decreased with the loading content of drug. After the Ce6 molecules were encapsulated into the micelles of CSO-SA, the cellular uptake percentage of Ce6 was much more than that of the free drug. And the cellular uptake percentage of CSO-SA/Ce6 micelles was increased with the incubation time in a short period. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHLORINE
*STEARIC acid
*CHITOSAN
*OLIGOSACCHARIDES
*MICELLES
Subjects
Details
- Language :
- English
- ISSN :
- 1061186X
- Volume :
- 17
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Drug Targeting
- Publication Type :
- Academic Journal
- Accession number :
- 43448407
- Full Text :
- https://doi.org/10.1080/10611860902894325