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Degradation of Activated Protein Kinases by Ubiquitination.
- Source :
-
Annual Review of Biochemistry . 2009, Vol. 78 Issue 1, p435-475. 41p. 5 Charts. - Publication Year :
- 2009
-
Abstract
- Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases. [ABSTRACT FROM AUTHOR]
- Subjects :
- *PROTEIN kinases
*CELLULAR signal transduction
*ORGANISMS
*UBIQUITIN
*GENOMES
Subjects
Details
- Language :
- English
- ISSN :
- 00664154
- Volume :
- 78
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Annual Review of Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 43347777
- Full Text :
- https://doi.org/10.1146/annurev.biochem.013008.092711