Associations of 25 Structural, Degradative, and Inflammatory Candidate Genes With Lumbar Disc Desiccation, Bulging, and Height Narrowing.

The article discusses the study which aims to examine the allelic diversity of structural, inflammatory and matrix-modifying gene candidates with disc degeneration. The study used 588 respondents who were associated with single-nucleotide polymorphisms in collagen, interleukin and matrix metalloproteinase genes with magnetic resonance imaging of disc desiccation. The study found accuracy of the quantitative disc signal intensity to support disc degeneration of polygenetic condition.