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l-Prolinol as a highly enantioselective catalyst for Michael addition of cyclohexanone to nitroolefins
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jul2009, Vol. 19 Issue 14, p3915-3918. 4p. - Publication Year :
- 2009
-
Abstract
- Abstract: Though many chiral amines such as l-proline and its derivatives have proven to be versatile catalysts in many reactions, l-prolinol was seldom used as organocatalyst for reactions. Herein, we report the first l-prolinol catalyzed asymmetric Michael addition of cyclohexanone to nitroolefins in the presence of benzoic acid to afford Michael adducts with high diastereoselectivities (87:13–>99:1) and enantioselectivities (82–96%). [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 19
- Issue :
- 14
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 43175075
- Full Text :
- https://doi.org/10.1016/j.bmcl.2009.03.076