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Serum levels of brain-derived neurotrophic factor in comorbidity of depression and alcohol dependence.
- Source :
-
Human Psychopharmacology: Clinical & Experimental . Jul2009, Vol. 24 Issue 5, p409-413. 5p. 2 Graphs. - Publication Year :
- 2009
-
Abstract
- Alcohol dependence is often comorbid with depression. The purpose of the present study was to compare serum brain-derived neurotrophic factor (BDNF) levels between depressive patients with and without alcohol dependence. Our subjects were 16 inpatients (M/F: 13/3, age: 48 ± 8 years) at our university hospital who met the DSM-IV-TR criteria for both major depressive disorder and alcohol dependence and whose Hamilton Rating Scale for Depression (HAM-D) scores were at least 15. Twenty sex- and age-matched depressive patients and 20 healthy subjects were also examined. Serum BDNF levels in the depressive patients with (9.0 ± 4.3 ng/ml) and without (9.8 ± 5.2 ng/ml) alcohol dependence were significantly lower than those in the healthy subjects (21.1 ± 7.0 ng/ml); however, no significant difference was found in the serum BDNF levels of depressive patients with and without alcohol dependence. Eight of the 16 (50%) depressive patients suffering from both depression and alcohol dependence responded to 8 weeks of treatment with antidepressant drugs which significantly increased their serum BDNF levels. These results suggest that the serum BDNF level is a useful biological marker for depression in patients with alcohol dependence. Copyright © 2009 John Wiley & Sons, Ltd. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ALCOHOLISM
*COMORBIDITY
*MENTAL depression
*PSYCHOPHARMACOLOGY
*PUBLIC health
Subjects
Details
- Language :
- English
- ISSN :
- 08856222
- Volume :
- 24
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Human Psychopharmacology: Clinical & Experimental
- Publication Type :
- Academic Journal
- Accession number :
- 42962455
- Full Text :
- https://doi.org/10.1002/hup.1035