Synthesis and biological activity of condensed derivatives of thieno[3,2- d]thiazolo(thiazino, thiazepino)[3,2- a]pyrimidines.

Methods for the synthesis of new heterosystems including condensed pyrano[4′,3′:4,5]pyrido[2,3- b]-thieno[3,2- d]thiazolo(thiazino, thiazepino)[3,2- a]pyrimidines, thiazolo(thiazino, thiazepino)[3″,2″:1′,2′]pyrimido[4′,5′:4,5]thieno[2,3- c]isoquinolines, and cyclopenta[4′,3′:4,5]pyrido[2,3- b]thieno[3,2- d]thiazolo(thiazino)[3,2- a]pyrimidines are developed. The synthesis is carried out on the basis of 1-amino-2-ethoxycarbonylpyrano[4,3- d]thieno[2,3- b]pyridines and -thieno[2,3- b]isoquinolines. Antitumor and anticonvulsant properties of the synthesized products have been evaluated. Compounds possessing low toxicity and moderate biological activity are found. [ABSTRACT FROM AUTHOR]