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A theoretical investigation of phosphonamidates and sulfonamides as protease transition state...

Authors :
Radkiewicz, Jennifer L.
McAllister, Michael A.
Goldstein, Elisheva
Houk, K. N.
Source :
Journal of Organic Chemistry. 03/06/98, Vol. 63 Issue 5, p1419. 10p. 8 Color Photographs, 6 Diagrams, 4 Charts, 1 Graph.
Publication Year :
1998

Abstract

Presents a theoretical investigation of phosphonamidates and sulfonamides as protease transition state isosteres. Methodology used; Information on two factors influencing the investigation; What has been attributed to the differences in the attitude of phosphonamidate and sulfonamide; Results and discussion of the study.

Subjects

Subjects :
*PHOSPHONATES
*SULFONAMIDES

Details

Language :
English
ISSN :
00223263
Volume :
63
Issue :
5
Database :
Academic Search Index
Journal :
Journal of Organic Chemistry
Publication Type :
Academic Journal
Accession number :
421759
Full Text :
https://doi.org/10.1021/jo971425f