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Structure-activity studies on the lycorine pharmacophore: A potent inducer of apoptosis in human leukemia cells
- Source :
-
Phytochemistry . May2009, Vol. 70 Issue 7, p913-919. 7p. - Publication Year :
- 2009
-
Abstract
- Abstract: The direct chemoselective differential functionalization of the ring-C hydroxyl groups present in the Amaryllidaceae alkaloid lycorine is described allowing for selective manipulation of the 1,2-hydroxyl groups. A mini-library comprised of synthetic and natural lycorane alkaloids was prepared and their apoptosis-inducing activity investigated in human leukemia (Jurkat) cells. Further insights into the nature of this interesting apoptosis-inducing pharmacophore are described, including the requirement of both free hydroxyl groups in ring-C. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00319422
- Volume :
- 70
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 42105784
- Full Text :
- https://doi.org/10.1016/j.phytochem.2009.04.012