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A systematic review on the clinical benefit and role of radiofrequency ablation as treatment of colorectal liver metastases

Authors :
Stang, Axel
Fischbach, Roman
Teichmann, Wolfgang
Bokemeyer, Carsten
Braumann, Dietrich
Source :
European Journal of Cancer. Jul2009, Vol. 45 Issue 10, p1748-1756. 9p.
Publication Year :
2009

Abstract

Abstract: Aim: To evaluate the role of radiofrequency ablation (RFA) as treatment of colorectal cancer liver metastases (CLMs). Method: A PubMed literature search for original articles published until August 2008 was performed. Studies with ⩾40 patients, ⩾18month median follow-up and reported ⩾3year overall survival (OS) rates after RFA of CLM were selected for analysis. Results: Thirteen clinical series and 8 non-randomised comparative studies were analysed. Median progression free survival after RFA ranged between 6 and 13months. Median and 5-year OS after RFA (RFA plus resection) ranged between 24–59months and 18–40% (36–46months and 27–30%). Comparative studies indicated significantly improved OS after RFA versus chemotherapy alone, RFA plus chemotherapy versus RFA alone and up-front RFA versus RFA following second-line chemotherapy. Conclusion: Our findings support that RFA prolongs time without toxicity and survival as an adjunct to hepatectomy and/or chemotherapy in well-selected patients, but not as an alternative to resection. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
09598049
Volume :
45
Issue :
10
Database :
Academic Search Index
Journal :
European Journal of Cancer
Publication Type :
Academic Journal
Accession number :
42104106
Full Text :
https://doi.org/10.1016/j.ejca.2009.03.012