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Effects of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in a mouse model of spinal cord injury.
- Source :
-
Free Radical Research . Jul2009, Vol. 43 Issue 7, p631-645. 15p. 8 Graphs. - Publication Year :
- 2009
-
Abstract
- The aim of the present study was to assess the effect of a metalloporphyrinic peroxynitrite decomposition catalyst, ww-85, in the pathophysiology of spinal cord injury (SCI) in mice. Spinal cord trauma was induced by the application of vascular clips to the dura via a four-level T5-T8 laminectomy. SCI in mice resulted in severe trauma characterized by oedema, neutrophil infiltration, production of inflammatory mediators, tissue damage and apoptosis. ww-85 treatment (30-300 µg/kg, i.p. 1 h after the SCI) significantly reduced in a dose-dependent manner: (1) the degree of spinal cord inflammation and tissue injury, (2) neutrophil infiltration (myeloperoxidase activity), (3) nitrotyrosine formation and PARP activation, (4) pro-inflammatory cytokines expression, (5) NF-κB activation and (6) apoptosis. Moreover, ww-85 significantly ameliorated the recovery of limb function (evaluated by motor recovery score) in a dose-dependent manner. The results demonstrate that ww-85 treatment reduces the development of inflammation and tissue injury associated with spinal cord trauma. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 10715762
- Volume :
- 43
- Issue :
- 7
- Database :
- Academic Search Index
- Journal :
- Free Radical Research
- Publication Type :
- Academic Journal
- Accession number :
- 41539768
- Full Text :
- https://doi.org/10.1080/10715760902954126