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Responsiveness of T Cells to Interleukin-7 Is Associated with Higher CD4+ T Cell Counts in HIV-1-Positive Individuals with Highly Active Antiretroviral Therapy-Induced Viral Load Suppression.
- Source :
-
Journal of Infectious Diseases . 6/15/2009, Vol. 199 Issue 12, p1872-1882. 11p. - Publication Year :
- 2009
-
Abstract
- Background. Despite suppression of the human immunodeficiency virus type1 (HIV-1)load by highly active antiretroviral therapy (HAART), recovery of CD4+ Tcell counts can be impaired. We investigated whether this impairment may be associated with hyporesponsiveness of T cells to γ-chain (γc) cytokines known to influence T cell homeostasis. Methods. The responsiveness of T cells to interleukin (IL)-2, IL-7, and IL-15 was determined by assessing cytokine-induced phosphorylation of the signal transducer and activator of transcription 5 (STAT5) in peripheral T cells obtained from 118 HIV-positive subjects and 13 HIV-negative subjects. Results. The responsiveness of T cells to interleukin (IL)-7 but not to IL-2 or IL-15 was lower among HIV-positive subjects than among HIV-negative subjects. Among subjects with viral load suppression, the degree of IL-7 responsiveness (1) correlated with naive CD4+ T cell counts and was a better immune correlate of the prevailing CD4+ T cell count than were levels of human leukocyte antigen-DR1 or programmed death-1, which are predictors of T cell homeostasis during HIV infection; and (2) was greater in subjects with complete (i.e., attainment of ⩾500 CD4+ T cells/mm³ ⩾5 years after initiation of HAART) versus incomplete immunologic responses. The correlation between plasma levels of IL-7 and CD4+ T cell counts during HAART was maximal in subjects with increased IL-7 responsiveness. Conclusions. Responsiveness of T cells to IL-7 is associated with higher CD4+ T cell counts during HAART and thus may be a determinant of the extent of immune reconstitution. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00221899
- Volume :
- 199
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Journal of Infectious Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 41534709
- Full Text :
- https://doi.org/10.1086/598858