Monocyte activation by necrotic cells is promoted by mitochondrial proteins and formyl peptide receptors.

The article presents a study which hypothesized that the mitochondrial fraction of the cell contributes to the monocyte activation by necrotic cells. Result shows that mitochondrial cell fractions activated monocytes and mitochondria from Rho(0) cells induced minimal monocyte Interleukin-8 release. They concluded that interactions between mitochondrial N-formyl peptides and formyl peptide receptor (FPR) in the presence of other mitochondrial antigens activated monocytes by necrotic cells.