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Matrix metalloproteinase 12 silencing: A therapeutic approach to treat pathological lung tissue remodeling?

Authors :
Garbacki, Nancy
Di Valentin, Emmanuel
Piette, Jacques
Cataldo, Didier
Crahay, Céline
Colige, Alain
Source :
Pulmonary Pharmacology & Therapeutics. Aug2009, Vol. 22 Issue 4, p267-278. 12p.
Publication Year :
2009

Abstract

Abstract: Among the large matrix metalloproteinases (MMPs) family, MMP-12, also referred to as macrophage elastase, plays a significant role in chronic pulmonary pathologies characterized by an intense tissue remodeling such as asthma and COPD. This review will summarize knowledge about MMP-12 structure, functions and mechanisms of activation and regulation, including potential MMP-12 modulation by microRNA. As MMP-12 is involved in many tissue remodeling diseases, efforts have been made to develop specific synthetic inhibitors. However, at this time, very few chemical inhibitors have proved to be efficient and specific to a particular MMP. The relevance of silencing MMP-12 by RNA interference is highlighted. The specificity of this approach using siRNA or shRNA and the strategies to deliver these molecules in the lung are discussed. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
10945539
Volume :
22
Issue :
4
Database :
Academic Search Index
Journal :
Pulmonary Pharmacology & Therapeutics
Publication Type :
Academic Journal
Accession number :
40629075
Full Text :
https://doi.org/10.1016/j.pupt.2009.03.001