Association of estrogen receptor α gene polymorphism with the presence of coronary artery disease documented by coronary angiography

Abstract: Objectives: To examine the relationship between PvuII and XbaI polymorphisms, with the presence of angiographically determined CAD in an Iranian population. Design and methods: Patients having angiographic evidence of atherosclerosis (Gensini score>6) in their epicardial coronary tree (CAD+ case group) were compared with Patients with Gensini score≤6 (CAD− control group). The presence of PvuII and XbaI polymorphisms was analyzed using polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP). Results: The PvuIΙ genotype distributions were not statistically different in CAD groups, and subgroups stratified by gender. For the XbaI polymorphism, after controlling for age, male sex, cigarette smoking and hyperlipidemia, XbaI GG genotype was not also found to be an independent predictor for CAD occurrence (OR=1.65; 95% CI: 0.90–3.03; P =0.10). Conclusions: We did not observe an association between ESR1 PvuII and XbaI gene polymorphisms with CAD in the risk of CAD in an Iranian population. [Copyright &y& Elsevier]