Solid-Phase Synthesis of 2,5-Dihydro-1H-pyrroles, 1,3-Dioxo-2,3,5,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazoles and 1,4-Dioxo-1,2,3,4,6,8a-hexahydropyrrolo[1,2-a]pyrazines Using a Supported Selenium Resin.

A versatile combinatorial approach was developed for the rapid synthesis of 2,5-dihydro-1H-pyrroles, 1,3-dioxo-2,3,5,7a-tetrahydro-1H-pyrrolo[1,2-c]imidazoles, and 1,4-dioxo-1,2,3,4,6,8a-hexahydropyrrolo[1,2-a]pyrazines libraries. The synthetic strategy includes electrophilic addition, dehydrohalogenation, 1,3-dipolar cycloaddition, N-acylation, amino carbonylation−cyclization, N-alkylation, lactamization, and oxidation−elimination. [ABSTRACT FROM AUTHOR]