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Parainfluenza virus type 5 (PIV-5) morphology revealed by cryo-electron microscopy
- Source :
-
Virus Research . Jun2009, Vol. 142 Issue 1/2, p200-203. 4p. - Publication Year :
- 2009
-
Abstract
- Abstract: The knowledge of parainfluenza type 5 (PIV-5) virion morphology is essentially based on the observation of negatively stained preparations in conventional transmission electron microscopy (CTEM). In this study, the ultrastructure of frozen-hydrated intact PIV-5 was examined by cryo-electron microscopy (cryo-EM). Cryo-EM revealed a majority of spherical virions (70%), with a lower pleiomorphy than originally observed in CTEM. Phospholipid bilayer thickness, spike length and glycoprotein spikes density were measured. About 2000 glycoprotein spikes were present in an average-sized spherical virion. Altogether, these data depict a more precise view of PIV-5 morphology. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 01681702
- Volume :
- 142
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Virus Research
- Publication Type :
- Academic Journal
- Accession number :
- 38802756
- Full Text :
- https://doi.org/10.1016/j.virusres.2008.12.017