Funkcjonalne znaczenie wzajemnej interakcji aktywności cyklooksygenazy-2, nabłonkowego czynnika wzrostu (EGF) i jego receptora w patogenezie przewlekłego zapalenia przełyku w świetle badań klinkznych i doświadczalnych

Barrett's esophagus (BE) is a precancerous condition leading to the development of adenocarcinoma, associated with intestinal metaplasia. Nowadays, the rapid increase in the incidence of esophageal adenocarcinoma (EAC) has been observed worldwide. Despite the surgical treatment and the introduction of new chemotherapy forms, the 5-year period survival is still bad. In this paper, we provide an update on the pathogenesis of BE and EAC based on the interrelationship between prostaglandins (PG), growth factors (GF), GF receptors and peroxisome proliferator-activated receptors (PPARs) in chronic esophagitis, BE, and EAC. We also attempted to overview the involvement of cyclooxygenase (COX) products and pharmacological inhibitors of COX in the process of proliferation, angiogenesis and apoptosis resulting from their interactions with PPARs. Furthermore, the paper presents some experimental animal models of inducing an acute and chronic esophagitis and Barrett's esophagus, which are useful in understanding the pathogenesis of these diseases under clinical settings. Among the potential pathomechanisms, the cellular processes resulting from transactivation GF receptors by other factors such as PG and their biological activity in chronic inflammation and carcinogenesis are emphasized. Finally, we stressed the impact of the naturally occurring anti-oncogenic mechanisms and the recent advances in the innovative therapy against gastrointestinal cancers. [ABSTRACT FROM AUTHOR]