Variants Within MECP2, a Key Transcription Regulator, Are Associated With Increased Susceptibility to Lupus and Differential Gene Expression in Patients With Systemic Lupus Erythematosus.

The article focuses on the efficacy of methyl-CpG-binding protein 2 gene (MECP2) polymorphisms as a key transcription regulator in the treatment of systematic lupus erythematosus (SLE). SLE is a chronic autoimmune disease which affect multiple organs including the brain and heart. The MECP2 served as a transcription activator in the majority of genes regulated by MECP2 in the murine hypothalamus. Details on the association of lupus within variants of MECP2 are discussed.