Back to Search
Start Over
Genetic immunization with the immunodominant antigen P48 of Mycoplasma agalactiae stimulates a mixed adaptive immune response in BALBc mice
- Source :
-
Research in Veterinary Science . Jun2009, Vol. 86 Issue 3, p414-420. 7p. - Publication Year :
- 2009
-
Abstract
- Abstract: A DNA vaccine against contagious agalactia was developed for the first time, encoding the P48 of Mycoplasma agalactiae. Specific immune responses elicited in BALB/c mice were evaluated. Both total IgG and IgG1 were detected in mice vaccinated with pVAX1/P48. Proliferation of mononuclear cells of the spleen, levels of gamma interferon, interleukin-12, and interleukin-2 mRNAs were enhanced in immunized animals. Results indicate that pVAX1/P48 vaccination induced both Th1 and Th2 immune responses. Nucleic acid immunization could be a new strategy against M. agalactiae infections and may be potentially used to develop vaccines for other Mycoplasma diseases. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00345288
- Volume :
- 86
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Research in Veterinary Science
- Publication Type :
- Academic Journal
- Accession number :
- 37819698
- Full Text :
- https://doi.org/10.1016/j.rvsc.2008.09.010