Glucagon response to exercise is critical for accelerated hepatic glutamine metabolism and....

Determines the role of glucagon in hepatic glutamine (Gln) metabolism during exercise in dogs. Implantation of sampling and infusion catheters and flow probes; Infusion of somatostatin throughout the study; Simulation of exercise-induced insulin decrement through the reduction of insulin infusion; Increase of hepatic Gln uptake and fractional extraction.