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Structural and antimicrobial studies of a new N-phenylamide of monensin A complex with sodium chloride
- Source :
-
Journal of Molecular Structure . Apr2009, Vol. 923 Issue 1-3, p53-59. 7p. - Publication Year :
- 2009
-
Abstract
- Abstract: A complex between a new N-phenylamide of monensin A (M-AM1) and sodium chloride has been synthesised and studied by X-ray diffraction and FT-IR spectroscopy. The crystal structure of the complex between M-AM1 and sodium chloride with acetonitrile was examined using X-ray diffraction and discussed in detail. Its structure is stabilised by coordination of the Na+ cation with oxygen atoms. The Na–O bond lengths are between 2.382(2) and 2.562(2)Å. The chloride anion is involved in a weak intermolecular hydrogen bond between different species forming a supramolecule. The ESI-MS spectra indicate that the amide forms stable complexes of exclusively 1:1 stoichiometry with Na+ cations. The FT-IR spectrum of the crystal is consistent with the results obtained by the X-ray study and provides spectroscopic evidence for the complex formation. Due to its specific structural properties N-phenylamide of monensin A efficiently binds sodium chloride. The result of the PM5 semiempirical calculation is in agreement with the spectroscopic data and allows visualisation of the structure of the M-AM1–Na+ complex. The new amide of monensin A has been additionally tested in view of its antimicrobial properties. It shows great activity towards some strains of Gram-positive bacteria (MIC=6.25–12.5μg/ml). [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 00222860
- Volume :
- 923
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- Journal of Molecular Structure
- Publication Type :
- Academic Journal
- Accession number :
- 37350939
- Full Text :
- https://doi.org/10.1016/j.molstruc.2009.01.056