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Inferring Human Colonization History Using a Copying Model.
- Source :
-
PLoS Genetics . May2008, Vol. 4 Issue 5, p1-11. 11p. 1 Diagram, 2 Graphs, 1 Map. - Publication Year :
- 2008
-
Abstract
- Genome-wide scans of genetic variation can potentially provide detailed information on how modern humans colonized the world but require new methods of analysis. We introduce a statistical approach that uses Single Nucleotide Polymorphism (SNP) data to identify sharing of chromosomal segments between populations and uses the pattern of sharing to reconstruct a detailed colonization scenario. We apply our model to the SNP data for the 53 populations of the Human Genome Diversity Project described in Conrad et al. (Nature Genetics 38,1251-60, 2006). Our results are consistent with the consensus view of a single ''Out-of-Africa'' bottleneck and serial dilution of diversity during global colonization, including a prominent East Asian bottleneck. They also suggest novel details including: (1) the most northerly East Asian population in the sample (Yakut) has received a significant genetic contribution from the ancestors of the most northerly European one (Orcadian). (2) Native South Americans have received ancestry from a source closely related to modern North- East Asians (Mongolians and Oroquen) that is distinct from the sources for native North Americans, implying multiple waves of migration into the Americas. A detailed depiction of the peopling of the world is available in animated form. [ABSTRACT FROM AUTHOR]
- Subjects :
- *GENOMES
*GENETIC polymorphisms
*HUMAN chromosomes
*CHROMOSOMES
*HUMAN genome
Subjects
Details
- Language :
- English
- ISSN :
- 15537390
- Volume :
- 4
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- PLoS Genetics
- Publication Type :
- Academic Journal
- Accession number :
- 37294911
- Full Text :
- https://doi.org/10.1371/journal.pgen.1000078