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Lower Serum Creatinine Is a New Risk Factor of Type 2 Diabetes.
- Source :
-
Diabetes Care . Mar2009, Vol. 32 Issue 3, p424-426. 3p. 1 Chart. - Publication Year :
- 2009
-
Abstract
- OBJECTIVE -- Because skeletal muscle is one of the target tissues for insulin, skeletal muscle mass might be associated with type 2 diabetes. Serum creatinine is a possible surrogate marker of skeletal muscle mass. The purpose of this study was to determine whether serum creatinine level is associated with type 2 diabetes. RESEARCH DESIGN AND METHODS-- The study participants were nondiabetic Japanese men (n = 8,570) aged 40-55 years at entry. Type 2 diabetes was diagnosed if fasting plasma glucose was ≥ 126 mg/dl or if participants were taking oral hypoglycemic medication or insulin. RESULTS-- During the 4-year follow-up period, 877 men developed type 2 diabetes. Lower serum creatinine was associated with an increased risk of type 2 diabetes. The multiple-adjusted odds ratio for those who had serum creatinine levels between 0.40 and 0.60 mg/dl was 1.91 (95% CI 1.44-2.54) compared with those who had levels between 0.71 and 0.80 mg/dl. CONCLUSIONS -- Lower serum creatinine increased the risk of type 2 diabetes. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01495992
- Volume :
- 32
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Diabetes Care
- Publication Type :
- Academic Journal
- Accession number :
- 37265257
- Full Text :
- https://doi.org/10.2337/dc08-1265