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Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features
- Source :
-
Schizophrenia Research . Apr2009, Vol. 109 Issue 1-3, p94-97. 4p. - Publication Year :
- 2009
-
Abstract
- Abstract: We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor β-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F=8.0, p=.031) and QPDTPHASE (chi-square=12.54, p=.028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square=15.51, p=.030), but not QTDT (chi-square=2.07, p=.560). [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 09209964
- Volume :
- 109
- Issue :
- 1-3
- Database :
- Academic Search Index
- Journal :
- Schizophrenia Research
- Publication Type :
- Academic Journal
- Accession number :
- 37229938
- Full Text :
- https://doi.org/10.1016/j.schres.2009.02.009