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Depletion of the programmed death-1 receptor completely reverses established clonal anergy in CD4+ T lymphocytes via an interleukin-2-dependent mechanism
- Source :
-
Cellular Immunology . Mar2009, Vol. 256 Issue 1/2, p86-91. 6p. - Publication Year :
- 2009
-
Abstract
- Abstract: Recent studies have implicated the cell surface receptor Programmed Death-1 (PD-1) in numerous models of T cell anergy, though the specific mechanisms by which the PD-1 signal maintains tolerance is not clear. We demonstrate that the depletion of PD-1 with siRNA results in a complete reversal of clonal anergy in the A.E7 T cell model, suggesting that the mechanism by which PD-1 maintains the anergic phenotype is a T-cell-intrinsic phenomenon, and not one dependent on other cell populations in vivo. We have also shown that the neutralization of IL-2 during restimulation abrogates the effect of PD-1 depletion, suggesting that tolerance mediated by PD-1 is wholly IL-2 dependent, and likewise intrinsic to the tolerized cells. [Copyright &y& Elsevier]
- Subjects :
- *GENOTYPE-environment interaction
*INTERLEUKIN-2
*CELL proliferation
*LYMPHOCYTES
Subjects
Details
- Language :
- English
- ISSN :
- 00088749
- Volume :
- 256
- Issue :
- 1/2
- Database :
- Academic Search Index
- Journal :
- Cellular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 36989267
- Full Text :
- https://doi.org/10.1016/j.cellimm.2009.01.008