A convenient synthesis of ortho–ortho disubstituted biphenyls containing an eight-membered lactam ring using radical chemistry

Authors :: Wang, C.H.
Alluri, S.
Ganguly, A.K.
Source :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Apr2009, Vol. 50 Issue 17, p1879-1881. 3p.
Publication Year :: 2009
Abstract: Abstract: Compound 4 prepared from Isatin in two steps underwent an unusual radical-induced rearrangement reaction to yield 9 as the major product and 10 as the minor component. Compound 9 shows structural similarities to the antimitotic agent rhazinilam and the gamma secretase inhibitor LY411575. The scope of the reaction has been studied by changing the substitutions on the aromatic rings and the mechanism for the formation of 9 and 10 from 4 is suggested. [Copyright &y& Elsevier]

Subjects :: *BIPHENYL compounds
*ORGANIC synthesis
*LACTAMS
*RADICALS (Chemistry)
*CHEMICAL reactions
*ORGANIC cyclic compounds
*CHEMICAL structure

Language :: English
ISSN :: 00404039
Volume :: 50
Issue :: 17
Database :: Academic Search Index
Journal :: Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry
Publication Type :: Academic Journal
Accession number :: 36969704
Full Text :: https://doi.org/10.1016/j.tetlet.2009.02.031

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