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Antioxidant properties of 1,2,3,4,6-penta-O-galloyl-β-d-glucose from Elaeocarpus sylvestris var. ellipticus

Antioxidant properties of 1,2,3,4,6-penta-O-galloyl-β-d-glucose from Elaeocarpus sylvestris var. ellipticus

Authors :
Piao, Mei Jing
Kang, Kyoung Ah
Zhang, Rui
Ko, Dong Ok
Wang, Zhi Hong
Lee, Keun Hwa
Chang, Weon Young
Chae, Sungwook
Jee, Youngheun
Shin, Taekyun
Park, Jae Woo
Lee, Nam Ho
Hyun, Jin Won
Source :
Food Chemistry. Jul2009, Vol. 115 Issue 2, p412-418. 7p.
Publication Year :
2009

Abstract

Abstract: The antioxidant potential of 1,2,3,4,6-penta-O-galloyl-β-d-glucose (PGG), isolated from Elaeocarpus sylvestris var. ellipticus, was investigated by various established systems based on cell-free and cell system experiments, such as radical detection, antioxidant enzyme assay, lipid peroxidation detection, and cell viability assay. PGG was found to quench the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species. PGG recovered the cellular antioxidant enzyme activities of superoxide dismutase, catalase, and glutathione peroxidase, which were reduced by H2O2 treatment, thereby resulting in the inhibition of lipid peroxidation. Cytoprotective effects of PGG were based on the results of DNA fragmentation, mitochondrial membrane potential (Δψ), apoptotic body formation, and caspase-3 activity. The results suggest that PGG protects cells against H2O2-induced cell damage via antioxidant properties. [Copyright &y& Elsevier]

Details

Language :
English
ISSN :
03088146
Volume :
115
Issue :
2
Database :
Academic Search Index
Journal :
Food Chemistry
Publication Type :
Academic Journal
Accession number :
36904599
Full Text :
https://doi.org/10.1016/j.foodchem.2008.12.020