Increased plasma leptin throughl-carnitine supplementation is associated with an enhanced glucose tolerance in healthy ponies.

In this study 0 or 4 g ofl-carnitine was supplemented for 7 days in a cross-over design of six healthy ponies to modulate glucose metabolism and leptin production. At the end of each period, serial blood samples were taken to measure glucose and insulin response, leptin, triglyceride (TG), non-esterified fatty acids (NEFA) and creatine phosphokinase.l-carnitine supplementation was associated with a decrease in postprandial plasma glucose and insulin concentration, indicating an enhanced glucose tolerance. In contrast, postprandial plasma leptin concentration was increased whenl-carnitine was supplemented. Yet, this increase in leptin concentration was not preceded by an increase in insulin concentration, suggesting that other factors apart from plasma insulin concentration could influence plasma leptin concentration. Although NEFA and TG were not significantly influenced byl-carnitine supplementation under these experimental conditions, further research must clarify whether net TG synthesis might be responsible for this increase in leptin. [ABSTRACT FROM AUTHOR]